Correlation of amino acid residues in the M1 and M2 proteins of influenza virus with high yielding properties
Identifieur interne : 002031 ( Main/Exploration ); précédent : 002030; suivant : 002032Correlation of amino acid residues in the M1 and M2 proteins of influenza virus with high yielding properties
Auteurs : A. I. Klimov [Russie] ; N. I. Sokolov [Russie] ; N. G. Orlova [Russie] ; V. P. Ginzburg [Russie]Source :
- Virus Research [ 0168-1702 ] ; 1991.
English descriptors
- Teeft :
- Academic press, Acid positions, Allantoic fluid, Amino, Amino acid residues, Amino acid sequence, Amino acid sequences, Amino acids, Avian, Avian viruses, Chick embryo cells, Complementary rnas, Embryonated eggs, Fertile eggs, Fowl plague viruses, Gene, Gene coding, Gene products, Growth properties, Hlnl, Human influenza virus, Human influenza viruses, Human strains, Influenza, Influenza virus, Influenza viruses, Klimov, Matrix protein gene, Molecular basis, Nakajima, Negative strand viruses, Nucleotide sequence, Other genes, Primary structure, Reassortant, Viral preparations, Virol, Virology, Virus, Virus yields.
Abstract
Abstract: The ability of influenza A viruses to replicate to high titer in the allantoic sac of the chicken embryo has been mapped to the matrix protein gene (RNA 7). Because influenza A/WSN/33 (H1N1) virus grows poorly in this host but contains a matrix protein gene with a sequence similar to sequences from viruses that grow well in eggs, we derived a single gene reassortant containing only the M gene from A/WSN/33 (H1N1) in a background of the other 7 RNA segments from A/ Philippines/2/82 (H3N2) (a low yielding virus, hy−). This reassortant replicated 10 times better than the A/WSN parent itself, indicating that the high yielding (hy+) phenotype of the A/WSN/33 M gene may be suppressed by one of the other genes of A/WSN/33. Comparison of M gene sequences between hy+ (including A/WSN/33) and hy− strains allowed us to correlate specific amino acid positions in M1 and M2 proteins with the growth properties of influenza viruses.
Url:
DOI: 10.1016/0168-1702(91)90098-G
Affiliations:
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Le document en format XML
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<term>Influenza virus</term>
<term>Influenza viruses</term>
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<front><div type="abstract" xml:lang="en">Abstract: The ability of influenza A viruses to replicate to high titer in the allantoic sac of the chicken embryo has been mapped to the matrix protein gene (RNA 7). Because influenza A/WSN/33 (H1N1) virus grows poorly in this host but contains a matrix protein gene with a sequence similar to sequences from viruses that grow well in eggs, we derived a single gene reassortant containing only the M gene from A/WSN/33 (H1N1) in a background of the other 7 RNA segments from A/ Philippines/2/82 (H3N2) (a low yielding virus, hy−). This reassortant replicated 10 times better than the A/WSN parent itself, indicating that the high yielding (hy+) phenotype of the A/WSN/33 M gene may be suppressed by one of the other genes of A/WSN/33. Comparison of M gene sequences between hy+ (including A/WSN/33) and hy− strains allowed us to correlate specific amino acid positions in M1 and M2 proteins with the growth properties of influenza viruses.</div>
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